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Jan Albrecht Selected Research

Glioma (Gliomas)

1/2016Glutamine Metabolism in Gliomas.
9/2015Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.
3/2014Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
11/2012Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents.
9/2010Direct exposure to ammonia and hyperammonemia increase the extracellular accumulation and degradation of astroglia-derived glutathione in the rat prefrontal cortex.
7/2009Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.
5/2008Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors.
6/2007Upregulation of cerebral cortical glutathione synthesis by ammonia in vivo and in cultured glial cells: the role of cystine uptake.
5/2006Selective decrease of SN1(SNAT3) mRNA expression in human and rat glioma cells adapted to grow in acidic medium.
8/2005Acrylamide stimulates glutamine uptake in Fischer 344 rat astrocytes by a mechanism involving upregulation of the amino acid transport system N.
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Jan Albrecht Research Topics

Disease

24Hepatic Encephalopathy
06/2021 - 02/2004
16Glioma (Gliomas)
01/2016 - 06/2002
15Acute Liver Failure (Fulminant Hepatic Failure)
01/2022 - 02/2004
14Brain Edema (Cerebral Edema)
01/2022 - 09/2003
11Hyperammonemia
01/2022 - 02/2004
9Neoplasms (Cancer)
03/2021 - 05/2008
8Glioblastoma (Glioblastoma Multiforme)
07/2020 - 02/2005
5Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 07/2007
5Brain Diseases (Brain Disorder)
01/2018 - 09/2003
5Liver Failure
02/2016 - 09/2003
3Seizures (Absence Seizure)
10/2021 - 06/2017
3Brain Neoplasms (Brain Tumor)
03/2021 - 02/2005
3Edema (Dropsy)
01/2021 - 12/2005
3Astrocytoma (Pilocytic Astrocytoma)
05/2008 - 09/2003
2Epilepsy (Aura)
09/2021 - 11/2010
2End Stage Liver Disease
02/2012 - 07/2009
2Memory Disorders (Memory Loss)
01/2012 - 11/2007
2Neoplasm Metastasis (Metastasis)
05/2006 - 03/2004
1Brain Injuries (Brain Injury)
09/2021
1Post-Traumatic Epilepsy (Epilepsy, Post Traumatic)
09/2021
1Neuroinflammatory Diseases
10/2020
1Central Nervous System Diseases (CNS Diseases)
11/2019
1Carcinogenesis
01/2019
1Neurologic Manifestations (Neurological Manifestations)
01/2018
1Temporal Lobe Epilepsy
06/2017
1Huntington Disease (Huntington's Disease)
02/2016
1Alzheimer Disease (Alzheimer's Disease)
09/2015
1Parkinson Disease (Parkinson's Disease)
09/2015
1Neurodegenerative Diseases (Neurodegenerative Disease)
09/2015
1Brain Ischemia (Cerebral Ischemia)
09/2015

Drug/Important Bio-Agent (IBA)

28AmmoniaIBA
01/2022 - 01/2003
18Glutamine (L-Glutamine)FDA Link
01/2022 - 09/2003
11Thioacetamide (Thioacetamid)IBA
06/2021 - 02/2004
10GlutaminaseIBA
07/2020 - 02/2005
9Glutamic Acid (Glutamate)FDA Link
10/2021 - 07/2007
9Messenger RNA (mRNA)IBA
02/2016 - 03/2004
7Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2021 - 11/2007
7Proteins (Proteins, Gene)FDA Link
02/2016 - 08/2005
5Protein Isoforms (Isoforms)IBA
03/2021 - 05/2008
4Kynurenic Acid (Kynurenate)IBA
12/2019 - 06/2002
4Histidine (L-Histidine)FDA Link
02/2016 - 03/2013
4Glutathione (Reduced Glutathione)IBA
02/2015 - 06/2007
4Cyclic GMPIBA
12/2014 - 03/2007
3Neurotransmitter Agents (Neurotransmitter)IBA
10/2021 - 06/2017
3EnzymesIBA
03/2021 - 09/2015
3AntioxidantsIBA
09/2015 - 03/2014
3NeurotoxinsIBA
09/2015 - 11/2010
3RNA (Ribonucleic Acid)IBA
01/2014 - 02/2005
3TaurineFDA Link
12/2005 - 01/2003
2Pilocarpine (Ocusert)FDA LinkGeneric
10/2021 - 01/2021
2Methionine SulfoximineIBA
10/2021 - 11/2010
2Arginine (L-Arginine)FDA Link
03/2021 - 02/2011
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
09/2015 - 12/2005
2Alkylating AgentsIBA
09/2015 - 11/2012
2Retinaldehyde (Retinal)IBA
02/2011 - 06/2004
2ammonium acetateIBA
09/2010 - 03/2004
2Natriuretic PeptidesIBA
05/2008 - 11/2007
1LithiumIBA
10/2021
1Biperiden (Akineton)FDA Link
09/2021
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
06/2021
1ArginaseIBA
03/2021
1SpermidineIBA
03/2021
1Nitric Oxide Synthase (NO Synthase)IBA
03/2021
1PolyaminesIBA
03/2021
1NexusIBA
03/2021
1Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
03/2021
1SpermineIBA
03/2021
1Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
01/2021
1Cholinergic Agents (Cholinergics)IBA
01/2021
1system N protein 1IBA
01/2021
1Bile Acids and Salts (Bile Acids)IBA
10/2020
1Quinolinic AcidIBA
12/2019
1Serotonin (5 Hydroxytryptamine)IBA
12/2019
12-oxindole (oxindole)IBA
12/2019
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2019
1DipeptidesIBA
02/2016
1CarnosineIBA
02/2016
1MetalsIBA
02/2016
1IronIBA
02/2016
1DNA (Deoxyribonucleic Acid)IBA
01/2016
1MercuryIBA
09/2015
1N,N-dimethylarginine (asymmetric dimethylarginine)IBA
09/2015
1dimethylargininaseIBA
09/2015
1dimethylarginineIBA
09/2015
1Amino AcidsFDA Link
02/2015
1ThioredoxinsIBA
02/2015
1Glutathione PeroxidaseIBA
02/2015
1serum P-component (CIt)IBA
12/2014
1CitrullineIBA
12/2014
1KynurenineIBA
06/2014
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
03/2014
1IsoenzymesIBA
03/2014
1Glutathione Disulfide (GSSG)FDA LinkGeneric
03/2014
1Coloring Agents (Dyes)IBA
03/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
03/2014
1Oxidants (Oxidizing Agents)IBA
03/2014
1Arsenic Trioxide (Trisenox)FDA Link
03/2014

Therapy/Procedure

3Drug Therapy (Chemotherapy)
09/2021 - 09/2015
2Therapeutics
03/2014 - 11/2010
1Radiotherapy
03/2021